{"id":58920,"date":"2021-06-19T11:34:00","date_gmt":"2021-06-19T09:34:00","guid":{"rendered":"https:\/\/www.fedaiisf.it\/?p=58920"},"modified":"2021-06-21T17:33:31","modified_gmt":"2021-06-21T15:33:31","slug":"vaccino-curevac-efficace-al-47-perche-ha-fatto-splash","status":"publish","type":"post","link":"https:\/\/www.fedaiisf.it\/en\/vaccino-curevac-efficace-al-47-perche-ha-fatto-splash\/","title":{"rendered":"CureVac vaccine effective at 47%. Because it splashed"},"content":{"rendered":"

CureVac's Covid mRNA vaccine fails test, effective only at 47%. The Financial Times article<\/em><\/span><\/h3>\n

 <\/p>\n

dthe<\/a><\/i> Start Magazine editorial board<\/strong>\u00a0\u2013 June 18, 2021<\/a><\/p>\n

\"\"German pharmaceutical company CureVac has revealed disappointing results from trials of its mRNA Covid-19 vaccine, dampening hopes that the vaccine could help meet the global need for effective inoculations.<\/p>\n

CureVac Wednesday he said<\/a> that its vaccine was 47 percent effective at protecting against the coronavirus in an interim analysis of its late-stage trials, making it one of the least effective coronavirus vaccines tested. ft<\/em><\/a>.<\/p>\n

US drugmaker Novavax this week said its protein-based vaccine is 90 percent effective at fighting the coronavirus, while Moderna and BioNTech\/Pfizer vaccines are 95 percent effective at tackling the original strain of the virus. .<\/p>\n

Shares of Nasdaq-listed CureVac tumbled 50 percent in the New York aftermarket on Wednesday.<\/p>\n

The company attributed the unsatisfactory results to strains of the virus circulating in 10 countries in Latin America and Europe, where trials were conducted.<\/strong><\/p>\n

In its 40,000-person study, CureVac said 13 variants were found in volunteers, with more than half of coronavirus cases caused by concern variants.<\/p>\n

However, data from the UK this week showed that BioNTech\/Pfizer's two-dose mRNA, or messenger ribonucleic acid, vaccine was effective at 96% in preventing hospitalization of people infected with the Delta variant, which has been detected for the first time in India.<\/p>\n

\"\"This week, the US Centers for Disease Control and Prevention added the Delta strain to its list of variants of concern.<\/p>\n

CureVac has partnered with German conglomerate Bayer to produce its coronavirus vaccine and has a deal with British pharmaceutical company GlaxoSmithKline to create a next generation of vaccines.<\/p>\n

The weak test results have questioned the feasibility of these designs. CureVac aims to produce 300 million doses of its vaccine this year and 1 billion in 2022.<\/p>\n

The company's shares have soared since its initial public offering in August 2020 as investors rushed to back the vaccine maker. CureVac had a cash position of \u20ac1.3 billion at the end of last year.<\/p>\n

\u201cWhile we hoped for a stronger interim result, we recognize that demonstrating high efficacy in this unprecedentedly broad diversity of variants is challenging,\u201d said Franz-Werner Haas, chief executive officer of CureVac. He added that the plethora of variants "highlights the importance of developing next-generation vaccines."<\/p>\n

The vaccine is also being studied in the UK as part of a booster study that involves giving several shots to people who have already received two doses of the Oxford\/AstraZeneca or BioNTech\/Pfizer vaccines.<\/p>\n

As with the Moderna and BioNTech\/Pfizer vaccines, CureVac's vaccine uses mRNA but its mRNA is natural and unmodified. Its vaccine also uses a lower dose, 12 micrograms compared to Moderna's 100mcg and BioNTech\/Pfizer's 30mcg, which results in a lower cost of production, and is stable at conventional refrigerator temperatures.<\/p>\n

CureVac said it will continue trials of its two-dose mRNA vaccine and decide on the most appropriate regulatory pathway after evaluating the final trial data.<\/p>\n

(Excerpt from the foreign press review by Epr Comunicazione)<\/em><\/p>\n

Related news:\u00a0CureVac Provides Update on Phase 2b\/3 Trial of First-Generation COVID-19 Vaccine Candidate, CVnCoV<\/a><\/p>\n

CureVac vaccine fails first tests, Italy expected 30.2 million doses<\/a><\/p>\n

Landazabal (GlaxoSmithKline) on Sky TG24: "Concentrate on developing new vaccines"<\/a> (CureVac)<\/p>\n

Novavax vaccine effective at 90% also against variants<\/a><\/p>\n

Astrazeneca breaks the silence: "Our vaccine saves lives and is also effective against the Delta variant"<\/strong><\/a><\/p>\n

EU Court agrees with AstraZeneca \/ "Give 80 million doses" Commission asked for 300<\/strong><\/a><\/p>\n

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Note: The CureVax vaccine for first clinical development, CVnCoV, is an optimized, chemically unmodified mRNA vaccine encoding the prefusion-stabilized Spike protein of SARS-CoV-2 virus and formulated in lipid nanoparticles (LNP)<\/em><\/p>\n

CureVac NV is a biopharmaceutical company, domiciled in the Netherlands but headquartered in T\u00fcbingen, Germany, developing mRNA-based therapies. The company's main activity is to develop vaccines against infectious diseases and drugs that treat cancer and rare diseases. It was founded in 2000 by Ingmar Hoerr (current CEO), Steve Pascolo (CSO), Florian von der Mulbe (COO), G\u00fcnther Jung and Hans-Georg Rammensee, CureVac as of May 2018 had 375 employees<\/em><\/p>\n

The Novavax vaccine<\/a> uses a different technology from that of the other vaccines approved so far: it is a protein-based vaccine that contains nanoparticles obtained from a laboratory version of the Spike protein present on the surface of Sars-Cov-2 and which uses an adjuvant substance to strengthen the immune responses. While mRna vaccines introduce the instructions to produce the spike protein into the body, the protein-based vaccine introduces the protein itself carried by small particles.\u00a0<\/em><\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

l vaccino mRNA anti Covid di CureVac fallisce il test, efficace solo al 47%. L\u2019articolo del Financial Times   di Redazione Start Magazine\u00a0– 18 giugno 2021 La societ\u00e0 farmaceutica tedesca CureVac ha rivelato risultati deludenti dalle prove del suo vaccino mRNA Covid-19, smorzando le speranze che il vaccino potrebbe aiutare a soddisfare il bisogno globale …<\/p>","protected":false},"author":4,"featured_media":58925,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[39],"class_list":["post-58920","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizie","tag-vaccini"],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/posts\/58920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/comments?post=58920"}],"version-history":[{"count":0,"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/posts\/58920\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/media\/58925"}],"wp:attachment":[{"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/media?parent=58920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/categories?post=58920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fedaiisf.it\/en\/wp-json\/wp\/v2\/tags?post=58920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}